Department of Internal Medicine, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI, 48109-0362, USA. Department of Medicine, Einstein Healthcare Network, Philadelphia, PA, USA. Department of Medicine, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY, USA. University of North Carolina, Chapel Hill, NC, USA. University of Southern California, Los Angeles, CA, USA. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Department of Internal Medicine, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI, 48109-0362, USA. rfontana@med.umich.edu.